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How humane is your endpoint? Improved refinement methods for infectious disease research.

"Research on chronic infection relies heavily on the use of animals, as only the integral animal body can model the full aspect of an infection. That animals are generally made to develop a disease in infection studies exacerbates the tension between human benefit and animal well-being, which characterizes all biomedical research with animals."

See: Franco NH, Correia-Neves M, Olsson IAS (2012) How "Humane" Is Your Endpoint?—Refining the Science-Driven Approach for Termination of Animal Studies of Chronic Infection. PLoS Pathog 8(1): e1002399. doi:10.1371/journal.ppat.1002399 (http://www.plospathogens.org/article/info%3adoi/10.1371/journal.ppat.1002399)

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